What question did this study set out to answer?

This research aims to evaluate the relevance of iron staining in bone marrow aspirates in the context of next-generation sequencing.

April 16, 2026

Utility of Iron Staining in Bone Marrow Aspirates in the Era of Next‐Generation Sequencing: A Retrospective Single‐Centre Study

Puntos clave

This research aims to evaluate the relevance of iron staining in bone marrow aspirates in the context of next-generation sequencing.
Conducted a retrospective analysis at a single center
Reviewed diagnostic classifications related to bone marrow iron staining
Assessed correlation between marrow iron grading and systemic iron status
Routine iron staining rarely influenced diagnostic classifications
Marrow iron grading showed a poor correlation with systemic iron status
Findings support a move towards a targeted approach to marrow iron assessment

Resumen

Routine bone marrow iron staining rarely influences diagnostic classification in contemporary practice. RS morphology is supportive but not determinative, and marrow iron grading correlates poorly with systemic iron status. These data support a targeted rather than routine approach to marrow iron staining, particularly where NGS is available and routinely performed in de novo diagnoses.

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Cite This Study

Ganeshalingam et al. (Tue,) studied this question.

synapsesocial.com/papers/69e07cfa2f7e8953b7cbe073 https://doi.org/https://doi.org/10.1111/ijlh.70114

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