ABSTRACT The synthesis of 2‐amino‐4H‐chromenes is described using itaconic acid as a catalyst in aqueous media. Under optimized reaction conditions, a variety of functionalized aromatic aldehydes, malononitrile, and α/β‐naphthol were reacted to afford 2‐amino‐4H‐chromene derivatives in excellent yields. This method is notable for its broad substrate scope, short reaction time, high efficiency, functional group tolerance, operational simplicity, and excellent catalyst recyclability. This makes the protocol feasible, economical, and environmentally benign.
SHELAR et al. (Wed,) studied this question.