Development of Orally Disintegrating Tablets from Solid Dispersions Containing Tolvaptan/Cyclodextrin Complexes

Puntos clave

• The study aims to develop an orally disintegrating tablet formulation using tolvaptan and cyclodextrin complexes to enhance solubility.
• Formulation of solid dispersions using tolvaptan and cyclodextrin.
• Assessment of solubility and dissolution rate compared to pure tolvaptan.
• Development of oral disintegrating tablets (ODTs).
• The new formulation shows increased solubility of tolvaptan compared to its pure form.
• The dissolution rate of the developed ODTs is higher than that of existing products.