Development of Orally Disintegrating Tablets from Solid Dispersions Containing Tolvaptan/Cyclodextrin Complexes | Synapse
April 17, 2026Open Access
Development of Orally Disintegrating Tablets from Solid Dispersions Containing Tolvaptan/Cyclodextrin Complexes
Puntos clave
The study aims to develop an orally disintegrating tablet formulation using tolvaptan and cyclodextrin complexes to enhance solubility.
Formulation of solid dispersions using tolvaptan and cyclodextrin.
Assessment of solubility and dissolution rate compared to pure tolvaptan.
Development of oral disintegrating tablets (ODTs).
The new formulation shows increased solubility of tolvaptan compared to its pure form.
The dissolution rate of the developed ODTs is higher than that of existing products.
Resumen
A new SD formulation with increased solubility and dissolution rate compared with pure tolvaptan was developed. The developed ODTs may be an alternative to the current commercial product.