Cross-Platform Concordance of Quantitative Amyloid PET Z-Scores in a Real-World Clinical Cohort of Patients with Cognitive Impairment and Suspected Alzheimer Disease

Puntos clave

• This research aims to evaluate the concordance of quantitative amyloid PET Z-scores across different software platforms in patients with cognitive impairment.
• Analyzed data from patients with cognitive impairment and suspected Alzheimer disease.
• Compared Z-scores from Syngo.Via and MIMneuro software packages.
• Investigated variability across regions and amyloid burden levels.
• Overall concordance was observed between the two software platforms.
• Significant variability was noted in specific brain regions and with varying amyloid burden.
• Findings indicate the need for cross-validation before using Z-scores from different platforms interchangeably.