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April 18, 2026Science0 citations

Shaping tissues with defects

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JDJohn W. C. Dunlop LKLucja Kowalewska

Puntos clave

Investigate how topological defects affect the geometric shapes of living cell sheets.
Analyzed cell sheet morphogenesis through topological defects
Performed geometric modeling to predict outcomes
Investigated various defect types in living cells
Identified specific defects that consistently guide cell sheet morphology
Demonstrated predictable structural transformations in response to defects
Showed improvements in tissue shape formation through manipulation of defects

Resumen

Topological defects encode geometric features that morph living cell sheets into predictable structures

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Cite This Study

Dunlop et al. (2026) studied this question.

synapsesocial.com/papers/69e320af40886becb653fd92 https://doi.org/https://doi.org/10.1126/science.aeg5982

Shaping tissues with defects | Synapse

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Guidance of cellular nematic elastomers into shape-programmable living surfaces2026 · 7 citations
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3Coupling anisotropic curvature and nematic order: mechanisms of membrane shape remodeling2025 · 2 citations
4Twisted plywood architecture of collagen fibrils in human compact bone osteons1988 · 490 citations
5Command of active matter by topological defects and patterns2016 · 254 citations