Mechanism of Modified Bixie Fenqing Drink in the Treatment of Henoch-Schnlein Purpura Nephritis Based on Network Pharmacology and Molecular Docking

Puntos clave

• The aim is to investigate the mechanism of a modified Bixie Fenqing drink in treating Henoch-Schönlein Purpura nephritis using network pharmacology and molecular docking.
• Utilized TCMSP database for drug components and target analysis.
• Identified disease targets and formed an intersection with drug targets.
• Constructed a network of intersection targets and performed PPI analysis and enrichment analysis (GO and KEGG).
• Conducted molecular docking between core targets and corresponding active ingredients.
• Identified 104 active components in the modified Bixie Fenqing drink and 397 drug targets.
• Found 303 disease targets, with 40 shared between drug and disease.
• Highlighted quercetin and gamma-aminobutyric acid as key active ingredients linked to significant targets like cyclooxygenase-2.
• Noted key regulatory pathways including fluid shear stress and atherosclerosis.