Background: Micronutrient status is a set of indicators characterizing the content and balance of macro- and microelements, vitamins in the body. These substances are necessary in small quantities; they play a key role in maintaining normal physiological processes, the functioning of the immune system, and tissue healing. Nutritional status is an important predictor of the wound healing process, since the presence of a wound negatively affects the nutritional status due to metabolic costs for the restoration of damaged tissue, sepsis, and loss of nutrients that occur through wound exudate. The aim of this systematic review is to summarize the data on the deficiency or excess of micronutrients, macronutrients, and vitamins in patients with diabetic foot ulcers (DFU). Methods: This review will use the Preferred Reporting Items for Systematic Reviews and Meta-analyses methodology. It will cover full-text articles from Scopus, PubMed, and Web of Science databases published in peer-reviewed and indexed journals. The review will include both experimental and observational studies on micronutrient status and their impact on the management, treatment, and healing of DFU. Article selection, data extraction, and quality assessment will be performed independently by four reviewers. Conclusions: The obtained results will allow a deeper study of the impact of micronutrients on diabetic foot therapy and will confirm the need to eliminate their deficiency. The authors plan to publish the results of the review in a peer-reviewed journal.
Batarbekova et al. (Sat,) studied this question.