November 24, 2011Open Access

CHEK2 contribution to hereditary breast cancer in non-BRCAfamilies

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Resumen

Our work indicates that a variety of deleterious CHEK2 alleles make an appreciable contribution to breast cancer susceptibility, and their identification could help in the clinical management of patients carrying a CHEK2 mutation.

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Desrichard et al. (Thu,) studied this question.

synapsesocial.com/papers/69e5c03c111e1f5ab3e70633 https://doi.org/https://doi.org/10.1186/bcr3062

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Testing for CHEK2 in the cancer genetics clinic: ready for prime time?2010 · 54 citations
2CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer2007 · 15 citations
3Chromosomal radiosensitivity of breast cancer with a mutation2005 · 15 citations
4Estrogen receptor status in CHEK2‐positive breast cancers: implications for chemoprevention2008 · 61 citations
5Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts2007 · 91 citations

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