TCF7L2 Polymorphisms and Progression to Diabetes in the Diabetes Prevention Program

Common variants in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance. The risk-conferring genotypes in TCF7L2 are associated with impaired beta-cell function but not with insulin resistance. (ClinicalTrials.gov number, NCT00004992. ClinicalTrials.gov).