Reduction of the TNS1 gene in vascular smooth muscle cells drives their transdifferentiation into macrophage-like cells and promotes atherosclerotic plaque instability.
Reduction of the TNS1 gene in vascular smooth muscle cells drives their transdifferentiation into macrophage-like cells, promoting atherosclerotic plaque instability.
Tasa de eventos absoluta: 0% vs 0%
The reduction of TNS1 gene in VSMCs might drive contractile VSMC transdifferentiation into MP-like SMC, the major subtype contributing to plaque instability. In vivo experimental results confirmed the role of Tns1 gene in contractile VSMC transdifferentiation into MP-like SMC and plaque instability.
Yang et al. (Wed,) reported a other. Reduction of the TNS1 gene in vascular smooth muscle cells drives their transdifferentiation into macrophage-like cells and promotes atherosclerotic plaque instability.