A holistic screening approach identified cardiac amyloidosis in 2% of aortic stenosis patients, utilizing predictors like male sex and carpal tunnel syndrome to achieve an AUC of 0.88.
Does a holistic screening approach based on multiorgan manifestations accurately identify cardiac amyloidosis in patients with aortic stenosis planned for valve replacement?
A holistic screening approach incorporating clinical symptoms, NT-proBNP, and echocardiographic features provides high diagnostic accuracy (AUC 0.88) for detecting concomitant cardiac amyloidosis in patients undergoing aortic valve replacement.
Tasa de eventos absoluta: 0% vs 0%
Abstract Aims Concomitant aortic stenosis (AS) and cardiac amyloidosis (CA) result in heart failure and reduced life expectancy. Early detection of CA in AS is an unmet clinical need to prevent disease progression. The SAVER study aims to establish a simple CA screening for AS patients. Methods and results SAVER is a prospective cohort study enrolling AS patients planned for transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR). Firstly, patients were assessed for CA-specific symptoms and history on top of AS evaluation. Patients with suspected CA underwent DPD scintigraphy or magnetic resonance imaging. Secondly, we performed multiple-regression analysis to identify optimal parameters for selecting patients at risk of CA. From 2021 to 2023, 1001 patients were enrolled, with 405 (40%) flagged for potential CA. Two hundred six (21%) patients received further diagnostics due to the screening and five (0.5%) patients due to physician discretion, leading to 17 (2%) confirmed CA cases. Key predictors of CA included male sex OR 23.8 (95% CI 2.6; 216.9), carpal tunnel syndrome OR 5.5 (95% CI 1.4; 22.0), spinal stenosis OR 4.1 (95% CI 1.1; 14.7), heaviness or numbness of arms or legs OR 3.8 (95% CI 1.1; 13.3), NT-proBNP OR 6.7 (95% CI 1.8; 25.3), and sparkling myocardium OR 4.8 (95% CI 1.3; 17.3). The optimized approach reached an AUC of 0.88 (95% CI 0.81–0.96). Conclusion The SAVER approach is the first holistic screening method focusing on CA’s multiorgan manifestations in AS. This approach can be implemented in clinical settings to prevent futile outcomes of combined disease.
Mattig et al. (Wed,) reported a other. A holistic screening approach identified cardiac amyloidosis in 2% of aortic stenosis patients, utilizing predictors like male sex and carpal tunnel syndrome to achieve an AUC of 0.88.