Intermittent normobaric hypoxic exposure and moderate-intensity exercise training provide complementary metabolic benefits in HFD-induced obese mice, and their combination yields additional improvements in key markers of body composition and glucose homeostasis. These findings support integrating hypoxic exposure with exercise as a potential non-pharmacological strategy to optimize metabolic health and motivate further mechanistic and translational studies.
Jang et al. (Thu,) studied this question.