April 25, 2026

Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock

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Resumen

Among children treated for septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction when fluid resuscitation was administered with balanced fluid as compared with 0.9% saline. (Funded by Eunice Kennedy Shriver National Institute of Child Health and Human Development and others; PRoMPT BOLUS ClinicalTrials.gov number, NCT04102371.).

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Balamuth et al. (Thu,) studied this question.

synapsesocial.com/papers/69ec870bb203de571d6f13da https://doi.org/https://doi.org/10.1056/nejmoa2601969

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial2021 · 51 citations
2Acute Management of Dengue Shock Syndrome: A Randomized Double-Blind Comparison of 4 Intravenous Fluid Regimens in the First Hour2001 · 352 citations
3Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study2020 · 7,773 citations
4Research Conditions That Qualify for Emergency Exception from Informed Consent2005 · 35 citations
5Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: The <scp>PR</scp>o<scp>MPT BOLUS</scp> Randomized Controlled Trial Pilot Feasibility Study2019 · 55 citations

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