The high-risk SCORE underestimated fatal CVD risk in Russian MONICA, performed well in most MONICA and HAPIEE samples, but may overestimate risk in Czech and Polish populations.
Does the high-risk SCORE model accurately predict fatal CVD risk in populations from Central and Eastern Europe and the former Soviet Union?
The high-risk SCORE model's performance varies significantly across Eastern European populations, highlighting the need for potential regional recalibration.
Tasa de eventos absoluta: 0% vs 0%
AIMS: The Systematic COronary Risk Evaluation (SCORE) scale assesses 10 year risk of fatal atherosclerotic cardiovascular disease (CVD), based on conventional risk factors. The high-risk SCORE version is recommended for Central and Eastern Europe and former Soviet Union (CEE/FSU), but its performance has never been systematically assessed in the region. We evaluated SCORE performance in two sets of population-based CEE/FSU cohorts. METHODS AND RESULTS: The cohorts based on the World Health Organization MONitoring of trends and determinants in CArdiovascular disease (MONICA) surveys in the Czech Republic, Poland (Warsaw and Tarnobrzeg), Lithuania (Kaunas), and Russia (Novosibirsk) were followed from the mid-1980s. The Health, Alcohol, and Psychosocial factors in Eastern Europe (HAPIEE) study follows Czech, Polish (Krakow), and Russian (Novosibirsk) cohorts from 2002-05. In Cox regression analyses, the high-risk SCORE ≥5% at baseline significantly predicted CVD mortality in both MONICA n = 15 027; hazard ratios (HR), 1.7-6.3 and HAPIEE (n = 20 517; HR, 2.6-10.5) samples. While SCORE calibration was good in most MONICA samples (predicted and observed mortality were close), the risk was underestimated in Russia. In HAPIEE, the high-risk SCORE overpredicted the estimated 10 year mortality for Czech and Polish samples and adequately predicted it for Russia. SCORE discrimination was satisfactory in both MONICA and HAPIEE. CONCLUSION: The high-risk SCORE underestimated the fatal CVD risk in Russian MONICA but performed well in most MONICA samples and Russian HAPIEE. This SCORE version might overestimate the risk in contemporary Czech and Polish populations.
Vikhireva et al. (Thu,) reported a other. The high-risk SCORE underestimated fatal CVD risk in Russian MONICA, performed well in most MONICA and HAPIEE samples, but may overestimate risk in Czech and Polish populations.