One traditional indicator of inflammation that is frequently utilized in clinical diagnosis and monitoring is erythrocyte sedimentation rate (ESR). The Westergren method is the industry standard, but it has drawbacks like low efficiency and vulnerability to external influences. ESR can be measured quickly with the Mindray BP200n automated hematology analyzer, which is based on dynamic turbidimetry. However, with little information from populations in the north, its reference interval has mostly been determined in southern China. By employing the Mindray BP200n, gender-specific ESR reference intervals for healthy adults will be established. Its clinical applicability will be assessed by comparing it to the modified Westergren method and evaluating interfering specimens. There were 5555 healthy adults receiving physical examinations at First Hospital of Shanxi Medical University. ESR reference intervals were calculated utilizing the Hoffmann method (P2.5-P97.5) in accordance with Chinese CLSI EP28-A3c and WS/T 402–2024. In routine and interfering specimens (hyperleukocytosis, cold agglutination), methodological evaluation compared BP200n with the ZC-100 analyzer and the Westergren method. CLSI criteria were met by gender-specific ESR reference intervals of 0–15 mm/h for males and 0–24 mm/h for females. With no discernible bias, BP200n demonstrated strong consistency with ZC-100 across clinical departments (Spearman r = 0.900–0.972). While ZC-100 displayed notable deviations, BP200n results for interfering specimens were in compliance with the Westergren method. The Mindray BP200n showed excellent consistency with the Westergren method and established trustworthy gender-specific ESR reference intervals in northern Chinese adults. Its clinical applicability as an effective and trustworthy ESR detection tool is supported by its consistent performance in difficult specimens.
Gao et al. (Fri,) studied this question.