Hypertensive patients on beta-blockers exhibited significantly lower systolic blood pressure at minute 6 of post-exercise recovery compared to those on ARBs (135 vs 143 mmHg, P=0.0157).
Cross-Sectional (n=50)
Does beta-blocker monotherapy improve hemodynamic attenuation during post-exercise recovery compared to ARB monotherapy in adults with hypertension?
Hypertensive patients on beta-blockers show greater attenuation of cardiovascular stress during post-exercise recovery compared to those on ARBs, which may impact the interpretation of exercise testing.
Tasa de eventos absoluta: 135% vs 143%
valor p: p=0.0157
Purpose: Recovery after exercise is a critical window for assessing cardiovascular regulation and medication effects. Because beta-blockers (BB) attenuate sympathetic activity, we hypothesized that hypertensive patients using BB would demonstrate greater hemodynamic attenuation during post-exercise recovery compared with those using angiotensin II receptor blockers (ARBs). Methods: Fifty adults with hypertension (19 on BB monotherapy and 31 on ARB monotherapy) underwent treadmill exercise testing with standardized blood pressure (BP) and heart rate (HR) measurements at rest, peak exercise, and throughout a 6-minute recovery period. Results: Baseline systolic blood pressure (SBP) was similar between groups (BB: 125 ± 2 mmHg vs . ARBs: 129 ± 2 mmHg, P = 0.2879). During recovery, BB users exhibited significantly lower SBP at all time points, including minute 6 (135 ± 10 vs . 143 ± 11 mmHg, P = 0.0157), with differences evident from minute 1 onward ( P < 0.05 for all). The rate–pressure product at recovery minute 6 was also lower in the BB group (12,260 ± 732 vs . 14,500 ± 401 mmHg·beats/min, P = 0.0056). HR during recovery was consistently lower among BB users at minutes 1, 2, 4, and 6 (all P < 0.05), reflecting blunted sympathetic drive. Conclusions: Hypertensive patients treated with BB exhibit greater attenuation of cardiovascular stress during post-exercise recovery compared with those using ARBs. These findings support a medication-specific effect on recovery hemodynamics, likely mediated by sympathetic blockade, with potential implications for exercise testing interpretation and cardiovascular risk stratification.
Braga et al. (Sun,) conducted a cross-sectional in hypertension (n=50). Beta-blockers vs. Angiotensin II receptor blockers was evaluated on Systolic blood pressure at minute 6 of post-exercise recovery (p=0.0157). Hypertensive patients on beta-blockers exhibited significantly lower systolic blood pressure at minute 6 of post-exercise recovery compared to those on ARBs (135 vs 143 mmHg, P=0.0157).