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July 22, 2011

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2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

KHKatrine Bagge HansenSteno Diabetes Centers MRMette M. RosenkildeUniversity of Copenhagen FKFilip K. KnopUniversity of Copenhagen

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Resumen

2OG and other 2-monoacylglycerols formed during fat digestion can activate GPR119 and cause incretin release from the human intestine. This mechanism is likely to contribute to the known stimulatory effect of dietary fat on incretin secretion, and it indicates that GPR119 is a fat sensor.

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Cite This Study

Hansen et al. (Fri,) studied this question.

synapsesocial.com/papers/69f0ccf02e59d4d1f98f2572 https://doi.org/https://doi.org/10.1210/jc.2011-0647

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans | Synapse

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