BACKGROUND: As a G protein-biased μ-opioid receptor agonist, oliceridine can offer a relatively effective and safe analgesia. However, its effect on patients suffering from kyphoplasty was unexplored. AIM: ) of oliceridine for analgesia during kyphoplasty in elderly patients across different age groups, providing clinical evidence for the optimal administration method. METHODS: of oliceridine was determined by Dixon's up-down sequential method. The manifestations of intraoperative analgesic insufficiency were defined as a Numerical Rating Scale (NRS) score ≥ 4, presence of body movement, an increased heart rate, or systolic and diastolic blood pressure > 20% from baseline during balloon dilation or bone cement injection. RESULTS: in the young-old group was significantly higher than that in the old age group. CONCLUSION: value in the old age group suggested that an increasing age might be associated with enhanced analgesic potency of oliceridine. The specific mechanism needs to be further elucidated in the future. TRIAL REGISTRATION: Chinese Clinical Trial Register: ChiCTR2400095085.
Miao et al. (Thu,) studied this question.