What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypertension (n=320). Intervention: Perceived stress. Primary outcome: Physical quality of life (AOR 0.887, 95% CI 0.842-0.935, p=<0.001).

What question did this study set out to answer?

This study investigates the link between stress and quality of life in hypertensive adults over 30 in Ghana.

April 29, 2026Open Access

Stress-induced effects on the quality of life among hypertensive adults in the Ashanti Mampong municipality, Ghana

Q: What are the key findings of this study?

Higher perceived stress was significantly associated with lower physical quality of life (AOR 0.887) among hypertensive adults.

Q: What question did this study set out to answer?

This study investigates the link between stress and quality of life in hypertensive adults over 30 in Ghana.

Resultado clave

Higher perceived stress was significantly associated with lower physical quality of life (AOR 0.887) among hypertensive adults.

Puntos clave

This study investigates the link between stress and quality of life in hypertensive adults over 30 in Ghana.
Cross-sectional mixed-methods design with 320 hypertensive adults aged 30 and above.
Quantitative data collected via PSS-10 and WHOQOL-BREF; qualitative data from focus groups and interviews.
Chi-square tests and logistic regression analyzed associations between stress and quality of life.
Higher stress correlated with reduced quality of life across all domains: physical (AOR = 0.887), psychological (AOR = 0.898), social (AOR = 0.918), and environmental (AOR = 0.915), all p < 0.001.
Perceived stress significantly varied by age, sex, education, employment, and income (p < 0.001).
Qualitative themes identified included financial strain and caregiving burden as exacerbating factors.

Diseño del estudio

Tipo

Cross-Sectional (n=320)

Multicéntrico

Sí

PICO estructurado

Is perceived stress associated with lower domain-specific quality of life among hypertensive adults?

Población

320 hypertensive adults aged 30 years and above in the Ashanti Mampong Municipality, Ghana

Intervención

Perceived stress (measured by PSS-10)

Resultado

Domain-specific quality of life (physical, psychological, social, and environmental well-being) measured by WHOQOL-BREFpatient reported

Higher perceived stress is significantly associated with lower physical, psychological, social, and environmental quality of life among hypertensive adults, highlighting the need for psychosocial support in hypertension management.

Resultado numérico

Estimación del efecto: AOR 0.887 (95% CI 0.842-0.935)

valor p: p=<0.001

Limitaciones

Conducted only in the Mampong Municipality, limiting generalizability to other regions of Ghana
Excluded adults with hypertension who do not attend clinics, introducing potential selection bias
Interviewer-administered questionnaires could have influenced responses due to social desirability or recall bias
Cross-sectional design prevents determining causality or changes over time
Some very ill patients were unable to participate
Potential residual confounding from unmeasured clinical factors such as duration of hypertension, comorbidities, and blood pressure control

Resumen

Hypertension remains one of the leading causes of illness and premature death worldwide, yet its emotional and social burden is often underestimated. This study examined the association between stress and domain-specific quality of life (QoL) among hypertensive adults aged 30 years and above in the Ashanti Mampong Municipality, Ghana. A cross-sectional mixed-methods design was employed among 320 hypertensive adults aged 30 years and above. Quantitative data were collected using the PSS-10 and WHOQOL-BREF, while qualitative insights were derived from focus group discussions with patients and interviews with healthcare providers. Chi-square tests examined associations between stress and sociodemographic factors, and logistic regression assessed relationships between stress and QoL domains. Qualitative data were thematically analysed. Chi-square analysis revealed that perceived stress varied significantly by age, sex, education, employment, and income (all p < 0.001), with higher stress observed among older adults, females, those with lower education, unemployed individuals, and lower-income participants. In the multivariable binary logistic regression, higher stress was associated with lower domain-specific QoL: physical (AOR = 0.887, 95% CI: 0.842–0.935, p < 0.001), psychological (AOR = 0.898, 95% CI: 0.862–0.935, p < 0.001), social (AOR = 0.918, 95% CI: 0.882–0.956, p < 0.001), and environmental well-being (AOR = 0.915, 95% CI: 0.879–0.954, p < 0.001). Qualitative findings further contextualized these results, highlighting themes of financial strain, caregiving burden, and fear of hypertension-related complications. Socioeconomic vulnerability intensifies stress and diminishes the QoL among people living with hypertension. Integrating stress screening, psychosocial counselling, and financial support within hypertension management policies is essential for improving patient outcomes.

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Cite This Study

Darko et al. (Mon,) conducted a cross-sectional in Hypertension (n=320). Perceived stress was evaluated on Physical quality of life (AOR 0.887, 95% CI 0.842-0.935, p=<0.001). Higher perceived stress was significantly associated with lower physical quality of life (AOR 0.887) among hypertensive adults.

synapsesocial.com/papers/69f19fd5edf4b468248068d2 https://doi.org/https://doi.org/10.1186/s12982-026-01697-5

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