Association of Body Roundness Index with all-cause and cardiovascular mortality in patients with cardiovascular-kidney-metabolic (CKM) syndrome stages 0–3: a cohort study

Objective: This study aimed to investigate the association of body roundness index (BRI) with all-cause and cardiovascular mortality in patients with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3. Methods: We analyzed data from 18,984 participants in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018. We employed Cox proportional hazards models, Fine-Gray proportional subdistribution hazards models, restricted cubic splines (RCS), and subgroup analysis to examine the associations between BRI and all-cause and cardiovascular mortality in patients with CKM syndrome stages 0-3. Results: for interaction <0.05) whereby the association was strongest among participants with less than high school diploma and current drinkers (for all-cause mortality), and among younger participants(< 50 years) and current smokers (for cardiovascular mortality). Conclusion: In CKM syndrome stages 0-3, BRI shows a U-shaped link to all-cause mortality but a linear association with cardiovascular mortality.