Patients with lung cancer were significantly more likely to initiate antidepressant therapy compared to those with colon, breast, or prostate cancer (adjusted ORs 1.9-2.5).
Observational (n=280,000)
Sí
Does lung cancer increase the risk of depression compared to colon, breast, or prostate cancer in patients with a first cancer diagnosis?
Patients with lung cancer have a substantially higher long-term risk of developing depression compared to those with colon, breast, or prostate cancer, highlighting the need for targeted psychiatric screening in this population.
Estimación del efecto: OR 1.9-2.5
valor p: p=<0.001
Depression is common among patients with cancer, but its occurrence may vary across cancer types with differing prognoses and symptom burdens. This nationwide study examined the long-term development of depression among patients with lung, colon, breast, and prostate cancer. Using Danish health registries (1998–2022), we identified all individuals with a first diagnosis of lung, colon, breast, or prostate cancer. Depression was assessed through hospital-based diagnoses or antidepressant prescriptions (≥ 2 dispensations within two years after diagnosis). Logistic regression models estimated odds ratios (ORs) for antidepressant initiation among cancer types, adjusted for age, marital status, municipality, educational attainment, and comorbidity (Quan adaptation of the Charlson Comorbidity Index). The study included more than 280,000 patients with cancer. Antidepressant use before diagnosis was more frequent among lung cancer compared with colon, breast, and prostate cancer. Following diagnosis, 1-year antidepressant use reached 16.8% in men and 24.9% in women with lung cancer, approximately twice the corresponding rates in other cancers. Adjusted analyses confirmed, that patients with lung cancer were more likely to initiate antidepressant therapy than those with colon, breast, or prostate cancer (adjusted ORs 1.9–2.5, p < 0.001). Depression diagnoses showed a similar, though less pronounced, pattern. Patients with lung cancer exhibit a substantially higher long-term risk of depression – even after adjustment compared to colon, breast, and prostate cancer - both before and after cancer diagnosis.
Borg et al. (Tue,) conducted a observational in Lung, colon, breast, and prostate cancer (n=280,000). Lung cancer vs. Colon, breast, or prostate cancer was evaluated on Antidepressant initiation (OR 1.9-2.5, p=<0.001). Patients with lung cancer were significantly more likely to initiate antidepressant therapy compared to those with colon, breast, or prostate cancer (adjusted ORs 1.9-2.5).