Transcatheter treatment of severe tricuspid regurgitation with the MitraClip system

AIM: The aim of this study was to show technical principles and feasibility of transcatheter tricuspid valve repair by use of the MitraClip system. METHODS AND RESULTS: Three consecutive patients were treated successfully for severe symptomatic Tricuspid regurgitation. Three-dimensional transoesophageal echocardiography confirmed reduction of measured effective regurgitant orifice in all patients effective regurgitant orifice area-baseline/post-procedure (cm(2)): 0.7/0.3; 1.5/0.8; 0.4/0.1, which was accompanied by an increase in left ventricular stroke volumes baseline/post-procedure (mL): 42.8/45.4; 38/45; 35.2/45, decrease of measured levels of N terminal pro brain natriuretic peptide (pg/mL: baseline/post-procedure: 548/440; 2526/1702; 1754/623), and significant relief of clinical symptoms for chronic right heart failure in all patients. CONCLUSIONS: Transcatheter tricuspid valve repair by use of interventional edge-to-edge repair with the MitraClip system was feasible, and safe in three consecutive patients. Reduction of tricuspid insufficiency associates with relief of clinical symptoms for right heart failure. This strategy seems a promising treatment option for patients at prohibitive surgical risk.