iObjective/ii:/i The purpose of this study is to look at the burgeoning topic of neuronutrition within nutritional neuroscience, specifically how dietary factors affect brain health, cognitive adaptation, and susceptibility to neurological illnesses across the lifetime.i Review framework/ii:/i This narrative review brings together current information from nutritional neuroscience, clinical trials, and epidemiological investigations to investigate the link between macronutrients, neurobiological mechanisms, and cognitive outcomes. The framework brings together molecular, physiological, and behavioural aspects to provide a thorough knowledge of diet-brain interactions.i Principle Theme:/i The review emphasises the importance of key nutrients such as proteins, carbs, fats (especially omega-3 fatty acids), vitamins, minerals, and phytonutrients in regulating brain chemistry, neurotransmitter production, neuroplasticity, and cognitive function. Core molecular pathways such as neuroinflammation, oxidative stress, and mitochondrial dysfunction are investigated in relation to neurological illnesses like Alzheimers disease, depression, and others. The gut-brain axis is described as a bidirectional communication system that influences mood and cognition via microbial metabolites, immunological signalling, and neurotransmitter synthesis. Hormonal imbalances and gene-environment interactions are also being investigated as modulators of neurogenesis and disease vulnerability, with potential ties to metabolic illnesses such as type 2 diabetes. Nutrient deficiencies, including protein, essential fatty acids, iron, zinc, iodine, and vitamin B12, have been linked to brain growth and cognitive decline.i Conclusion:/i Neuronutrition offers a multidisciplinary approach for examining how dietary habits influence neuronal integrity and cognitive resilience. The evidence supports the creation of specific dietary therapies aiming at improving brain health, reducing neuroinflammation, and lowering the global prevalence of neurological and metabolic illnesses. Future research should focus on mechanistic clarity and translational techniques to improve cognitive health in varied populations.
Jangra et al. (Mon,) studied this question.