Hypoxemia and hypercapnia synergistically mediates peripheral vasoconstriction whereas hypercapnia mediates cerebral vasodilation in resting humans

. By contrast, Δ CVCi did not differ between the summed isolated vs. Combined (P = 1.000). We show that hypoxemia and hypercapnia interact to augment systemic vasoconstriction, whereas hypercapnia-induced cerebral vasodilation is well preserved when combined with hypoxemia.