Advanced GC Method for Comprehensive Residual Solvent Analysis: Overcoming Co-elution with Orthogonal Columns and Quantification by Mass Spectrometry

Puntos clave

• To develop a comprehensive gas chromatographic method for identifying residual solvents.
• Developed a gas chromatographic method
• Targeted 57 residual solvents listed in ICH guidelines
• Achieved analysis in a single 30-minute chromatogram
• Identified and quantified residual solvents efficiently
• Overcame challenges of co-elution with orthogonal columns