New benzochromene-based compounds as potential EGFR-TK inhibitors: synthesis, anti-proliferative activity, molecular docking studies, and ADME profiles

Puntos clave

• This research investigates the synthesis and anti-cancer potential of new benzochromene-based compounds targeting EGFR-TK.
• Synthesis of new benzochromene compounds for evaluation.
• Assessment of anti-proliferative activity in cancer cell lines.
• Molecular docking studies to predict interactions with EGFR.
• Compound 7 significantly inhibited EGFR, demonstrating potent anti-cancer activity.
• Activity of compound 7 was comparable to gefitinib.
• Molecular docking results indicated favorable binding affinity to the EGFR-TK domain.