What question did this study set out to answer?

This report aims to illustrate rare, severe complications arising from osteomyelitis in healthy children.

May 6, 2026Case Reports in Pediatrics0 citationsOpen Access

Uncommon Complications of Osteomyelitis: Deep Vein Thrombosis and Pulmonary Septic Emboli in Two Healthy Pediatric Patients: A Case Report and Literature Review

HAHala O. AbdallahAn-Najah National University LMLara Haj MohammedAn-Najah National University HOHobab Jehad OdehAlexandria University

Puntos clave

This report aims to illustrate rare, severe complications arising from osteomyelitis in healthy children.
Case report of two pediatric patients with osteomyelitis and complications; literature review of similar cases.
Management involved targeted intravenous antibiotics and anticoagulation alongside surgical intervention.
Both patients presented with limb pain and fever, developing deep vein thrombosis and pulmonary septic emboli later.
MRI confirmed multifocal bone involvement with abscesses, necessitating drainage.

Resumen

(MRSA) bacteremia. Both children initially presented with nonspecific limb pain, fever, and markedly elevated inflammatory markers, with early imaging proving nondiagnostic. Each subsequently developed venous thrombosis and septic emboli prior to confirmation of osteomyelitis, reflecting an aggressive clinical pattern. MRI later revealed multifocal bone involvement with subperiosteal abscesses requiring surgical drainage. Management required prolonged targeted intravenous antibiotics, anticoagulation, and coordinated multidisciplinary care. These cases highlight the importance of early suspicion for musculoskeletal infection in febrile children with persistent limb pain and systemic MRSA infection. Early MRI and prompt recognition of thromboembolic complications are essential for improving outcomes.

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