A 54-year-old female presenting with macroglossia and dyspnea on exertion was diagnosed with heart failure with preserved ejection fraction due to cardiac amyloidosis secondary to multiple myeloma.
Case Report (n=1)
This case highlights the importance of recognizing macroglossia as a potential clinical sign of cardiac amyloidosis in patients presenting with HFpEF.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by abnormal diastolic dysfunction and increased filling pressures. Cardiac amyloidosis is one of the causes of HFpEF. Macroglossia refers to a generalized enlargement of the tongue. The causes are varied, ranging from benign conditions like hypothyroidism to sinister conditions like malignancy. We present the case of a 54-year-old female with macroglossia and dyspnea on exertion. On evaluation, she was found to have HFpEF due to cardiac amyloidosis. Further workup confirmed multiple myeloma, and she was initiated on chemotherapy.
Kintada et al. (Mon,) conducted a case report in Heart failure with preserved ejection fraction (HFpEF) and macroglossia (n=1). Chemotherapy was evaluated. A 54-year-old female presenting with macroglossia and dyspnea on exertion was diagnosed with heart failure with preserved ejection fraction due to cardiac amyloidosis secondary to multiple myeloma.