What question did this study set out to answer?

This study investigates the relationship between damage-associated molecular patterns and peripheral hypoperfusion in sepsis.

May 8, 2026Open Access

High-mobility group box 1 protein, histone H3 and histone H4 are not associated with peripheral hypoperfusion in sepsis: a retrospective cohort study

Puntos clave

This study investigates the relationship between damage-associated molecular patterns and peripheral hypoperfusion in sepsis.
Retrospective cohort study design
Assessment of serum levels of high-mobility group box 1, histone H3, and histone H4
Comparison of peripheral perfusion outcomes between survivors and non-survivors
Survivors had better peripheral perfusion compared to non-survivors.
No significant correlation between mortality and serum levels of the evaluated patterns.
Levels of damage-associated molecular patterns were similar in patients with reduced and normal peripheral perfusion.

Resumen

Highlights ■ This study aimed to evaluate the association between damage-associated molecular patterns and peripheral hypoperfusion in sepsis. ■ Surviving patients showed better peripheral perfusion than non-survivors. ■ No significant association was observed between mortality and serum levels of the evaluated damage-associated molecular patterns. ■ Damage-associated molecular patterns levels did not differ between patients with reduced or normal peripheral perfusion. ABSTRACT Objective: The causal mechanisms of peripheral hypoperfusion in sepsis have not yet been fully elucidated. Therefore, this study aimed ...

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