This manuscript is Volume VI of the program that seeks to axiomatize chemistry within the established global-realist framework. Its purpose is to complete the chemistry program by deriving analytical chemistry and molecular recognition from the already closed ontology of matter, rather than treating spectra, retention times, mass peaks, currents, or binding readouts as primitive laboratory tokens. We argue that every admissible analytical act has one common physical structure: a declared external probe perturbs an already-defined molecular or supramolecular target, the target responds through one or more internal disturbance-field channels, and an instrument records a reduced signal from which one infers the underlying chemical state subject to admissibility constraints. On this basis we formulate a unified forward map from chemical organization to observable signal spaces, derive resonance and transition-selection conditions, show how Beer–Lambert attenuation emerges as a macroscopic counting law for repeated microscopic absorption events, formulate chromatographic retention as a transport–partition competition, reconstruct mass spectrometry as controlled ionization plus field-guided trajectory separation, and treat vibrational, electronic, magnetic resonance, electrochemical, and surface measurements as specialized probe–response branches of the same common analytical skeleton. Molecular recognition is then derived as a selective analytical pushforward of host–guest binding thermodynamics, kinetics, and signal transduction. The inverse problem is subsequently formulated as constrained posterior selection on the already exported state-description layer of Volume V, with explicit treatment of identifiability, resolution, regularization, and multimodal fusion. We conclude by proving a closure theorem: once the forward and inverse analytical layers are added, the chemistry program is complete both on what matter is and on how matter is read. No primitive laboratory semantics remain; every admissible analytical verdict is a derived projection of previously defined chemical ontology under declared probe conditions.
Jianming Wang (Wed,) studied this question.