What question did this study set out to answer?

This study aims to establish a framework linking within-host dynamics and population-level epidemic behaviors.

May 8, 2026Open Access

From Trait-Structured Within-Host Dynamics to SIR Models: A Multiscale Framework With Re-Exposure

Puntos clave

This study aims to establish a framework linking within-host dynamics and population-level epidemic behaviors.
Developed a multiscale framework bridging immunological dynamics and SIR models.
Analyzed the influence of within-host measurements on epidemic indicators and control thresholds.
Identified a relationship between immunological heterogeneity and chronic reservoirs.
Estimated control thresholds directly from within-host data, enhancing prediction of epidemic dynamics.

Resumen

, producing backward-bifurcation-like behavior at the population level. The framework provides a consistent route from immunological heterogeneity to epidemic indicators, with implications for identifying chronic reservoirs, interpreting dose-response data, and estimating control thresholds directly from within-host measurements.

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Authors

Cyrille Kenne

University of British Columbia

Pascal Zongo

Université des Antilles

Journals

Bulletin of Mathematical Biology

Actions

Institutions

University of British Columbia

Université des Antilles

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

From Trait-Structured Within-Host Dynamics to SIR Models: A Multiscale Framework With Re-Exposure

Puntos clave

Resumen

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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