Structural tuning of diclofenac for enhanced medicinal efficacy and reduced adverse effects: an integrating computational validation
Puntos clave
This research aims to modify diclofenac's structure to improve its therapeutic effects while minimizing adverse effects.
Incorporation of heterocyclic moieties into the diclofenac structure.
Computational validation to assess the new formulations.
Analysis of therapeutic efficacy and adverse effects.
The modified diclofenac exhibited enhanced therapeutic efficacy.
Reduced adverse effects were observed with the structural changes.
Computational models confirmed the potential benefits of the new formulations.
Resumen
The structure of diclofenac was modified through the incorporation of heterocyclic moieties to enhance therapeutic efficacy and reduce adverse effects.