Objectives/Goals: To generate actionable insights into the commercialization process in academic translational science by using comparative case studies to identify strategies, success factors, and challenges across CTSA hubs, informing best practices for innovators and institutions. Methods/Study Population: We will employ a comparative case study approach, engaging 11 CTSA hubs to document two or more product-specific commercialization case studies, including at least one successful and one unsuccessful example. To ensure the comprehensiveness and consistency of data collection and analysis across cases, a standardized framework developed by the TCSC WG is followed by all participating hubs for both quantitative data (e.g., milestones, funding) and qualitative insights (stakeholder interviews). Coding and downstream cross-case analysis is leveraged to identify unifying themes and discriminating factors in commercialization strategies and associations with success and failure. Results/Anticipated Results: We aim to identify patterns, barriers, and catalysts in academic commercialization, defining key resources along with effective practices and strategies. Findings will clarify the role of CTSA hubs and their collaboration with institutional partners such as Technology Transfer. Results will highlight best practices in IP management, funding, team dynamics, partnerships, and regulatory navigation. A comparative analysis across CTSA hubs will yield a case study repository, cross-case report, educational materials, and a peer-reviewed publication. Collectively, we expect findings to provide practical guidance to NCATS and academic institutions for accelerating biomedical innovation. Discussion/Significance of Impact: This study fills a critical gap by providing real-world, comparative insights into the commercialization process within academic medicine. Outcomes will support CTSA hubs, healthcare systems, innovators, and policymakers in improving translational efficiency and maximizing innovation impact.
Gomez et al. (Wed,) studied this question.