K37 mutations, an outer membrane porin previously linked to carbapenem resistance. A number of antibiotic resistance genes were found on conjugative plasmids (IncFIB/IncFII, IncFIA, IncFIA/IncFII). Multilocus sequence typing identified different sequence types (ST307, ST45) and virulence profiling showed overlapping and distinct features, including variability in capsular and siderophore genes. These findings suggest a significant role for porin loss and efflux pump regulation in conferring resistance to broad-spectrum and last-resort antibiotics in clinical XDR-KP isolates that lack carbapenemases and other related antibiotic resistance genes.
Fatima et al. (Thu,) studied this question.