An easy synthetic protocol for imidazo‐1,4‐oxazines and evaluation of their toxicities

Abstract Imidazo‐1,5‐alkynyl alcohol derivatives were synthesized, and they were cyclized to imidazo‐1,4‐oxazines by means of cesium carbonate. Propargyl‐allene isomerization was examined, and the reaction mechanism was proposed. Moreover, cytotoxicity of synthesized molecules against LN 405 cell lines was investigated by means of structure‐activity relationship ( SAR ). With SAR study, toxicities of some functional groups have been shown. In addition, two lead compounds were tested against DNA damaging.