T2‐based MRI Delta‐radiomics improve response prediction in soft‐tissue sarcomas treated by neoadjuvant chemotherapy.

BACKGROUND: Standard of care for patients with high-grade soft-tissue sarcoma (STS) are being redefined since neoadjuvant chemotherapy (NAC) has demonstrated a positive effect on patients' outcome. Yet response evaluation in clinical trials still relies on RECIST criteria. PURPOSE: To investigate the added value of a Delta-radiomics approach for early response prediction in patients with STS undergoing NAC. STUDY TYPE: Retrospective. POPULATION: Sixty-five adult patients with newly-diagnosed, locally-advanced, histologically proven high-grade STS of trunk and extremities. All were treated by anthracycline-based NAC followed by surgery and had available MRI at baseline and after two chemotherapy cycles. FIELD STRENGTH/SEQUENCE: -WI at 1. 5 T. ASSESSMENT: A threshold of <10% viable cells on surgical specimens defined good response (Good-HR). Two senior radiologists performed a semantic analysis of the MRI. After 3D manual segmentation of tumors at baseline and early evaluation, and standardization of voxel-sizes and intensities, absolute changes in 33 texture and shape features were calculated. STATISTICAL TESTS: Classification models based on logistic regression, support vector machine, k-nearest neighbors, and random forests were elaborated using crossvalidation (training and validation) on 50 patients ("training cohort") and was validated on 15 other patients ("test cohort"). RESULTS: Sixteen patients were good-HR. Neither RECIST status (P = 0. 112) nor semantic radiological variables were associated with response (range of P-values: 0. 134-0. 490) except an edema decrease (P = 0. 003), although 14 shape and texture features were (range of P-values: 0. 002-0. 037). On the training cohort, the highest diagnostic performances were obtained with random forests built on three features: ΔHistogramEntropy, ΔElongation, ΔSurroundingEdema, which provided: area under the curve the receiver operating characteristic = 0. 86, accuracy = 88. 1%, sensitivity = 94. 1%, and specificity = 66. 3%. On the test cohort, this model provided an accuracy of 74. 6% but 3/5 good-HR were systematically ill-classified. DATA CONCLUSION: -based Delta-radiomics approach might improve early response assessment in STS patients with a limited number of features. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50: 497-510.