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Highly Enantioselective Alkylation Reaction of Enamides by Brønsted-Acid Catalysis | Synapse

September 11, 2009

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Highly Enantioselective Alkylation Reaction of Enamides by Brønsted-Acid Catalysis

QGQi‐Xiang GuoSouthwest University YPYungui PengSouthwest University JZJinwei ZhangZhengzhou University

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Resumen

The H8-BINOL-derived, phosphoric acid catalyzed, highly enatioselective alkylation reaction of enamides with indolyl alcohols has been described. A phosphoric acid derived from H8-BINOL enabled an asymmetric alpha-alkylation of enamides with indolyl alcohols to give beta-aryl 3-(3-indolyl)propanones in high yields (up to 96%) and with excellent enantioselectivity (up to 96% ee).

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Cite This Study

Guo et al. (Fri,) studied this question.

synapsesocial.com/papers/69ffd0e9b124fe581985a199 https://doi.org/https://doi.org/10.1021/ol901892s

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