Does midodrine hydrochloride improve symptoms and cure rates in children with postural orthostatic tachycardia syndrome compared to metoprolol or conventional therapy?
Midodrine hydrochloride added to conventional therapy significantly improves cure rates and symptom scores in children with POTS compared to metoprolol or conventional therapy alone.
BACKGROUND: The study was carried out to examine the effect of selective α1 adrenoceptor agonist midodrine hydrochloride vs. β-adrenergic blockade metoprolol in the treatment of children with postural orthostatic tachycardia syndrome (POTS). METHODS AND RESULTS: Fifty-three children with POTS were divided into group I (midodrine hydrochloride plus conventional therapy), group II (metoprolol plus conventional therapy) and group III (conventional therapy). Standing test was conducted for all participants. The cure rate, improvement rate, effective rate and score of symptoms were compared among the 3 groups. A Kaplan-Meier survivorship curve was used to describe the proportion of symptom-free cases during a long term follow-up. The cure rate and effective rate at the end of short term follow-up in group I were significantly higher than those of group II and group III (68.42% vs. 42.11% vs. 20.00%, P0.05). CONCLUSIONS: Midodrine hydrochloride is effective in the treatment of children with POTS.
Chen et al. (Sat,) studied this question.
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