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Isoniazid metabolism and hepatotoxicity | Synapse

August 4, 2016Open Access

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Isoniazid metabolism and hepatotoxicity

PWPengcheng WangShenyang Agricultural University KPKomal PradhanMerck & Co., Inc., Rahway, NJ, USA (United States)XZXiao-bo ZhongUniversity of Connecticut

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Resumen

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.

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Wang et al. (Thu,) studied this question.

synapsesocial.com/papers/69ffe5abb124fe581985abca https://doi.org/https://doi.org/10.1016/j.apsb.2016.07.014

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effect of Isoniazid on the Loss of Pyridoxal Phosphate from, and its Distribution in, the Body of the Rat1966 · 15 citations
2Molecular Biology of the Enzymes that Degrade Endocannabinoids2005 · 29 citations
3Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans.1985 · 76 citations
4Role of cytochrome P450 in hydrazine toxicity in isolated hepatocytes in vitro1995 · 31 citations
5Penetration of isoniazid, rifampicin and pyrazinamide in tuberculous pleural effusion and psoas abscess.2004 · 22 citations