What is the clinical evidence from this study?

Study design: Observational. Population: Aortic valve disease (n=42). Intervention: Carpentier Edwards PERIMOUNT valve. Primary outcome: Mortality.

What question did this study set out to answer?

To evaluate the durability, haemodynamic performance, survival, and clinical outcomes following aortic valve replacement with the Carpentier Edwards PERIMOUNT valve.

May 10, 2026Open Access

Durability, Haemodynamic Performance, and Clinical Outcomes of the Carpentier Edwards PERIMOUNT Valve in the Indian Population

Resultado clave

The Carpentier Edwards PERIMOUNT valve demonstrated an estimated 5-year survival of 92.9% and a low structural valve deterioration rate of 2.38% following aortic valve replacement.

Puntos clave

To evaluate the durability, haemodynamic performance, survival, and clinical outcomes following aortic valve replacement with the Carpentier Edwards PERIMOUNT valve.
Single-centre retrospective observational study
Included 42 patients who underwent aortic valve replacement
Followed patients at mid-term (6 months) and long-term (5 years)
Mean effective orifice area increased from 1.3 cm² preoperatively to 1.9 cm² at 5 years
Estimated 5-year survival rate was 92.86%
2.38% of patients required redo aortic valve replacement for structural valve deterioration

Diseño del estudio

Tipo

Observational (n=42)

Multicéntrico

PICO estructurado

Población

42 adults (aged ≥18 years) undergoing aortic valve replacement (AVR) for aortic valve disease (85.72% aortic stenosis), mean age 67.42, 76.19% male, Indian cohort.

Intervención

Aortic valve replacement (AVR) with the bovine pericardial bio-prosthesis (Carpentier-Edwards PERIMOUNT, Model 2800TFX)

Resultado

Mortality and Major Adverse Cardiac and Cerebrovascular Events (MACCE), defined as readmission for heart failure, thromboembolism, infective endocarditis, or structural valve deterioration (SVD) at 5 yearscomposite

The Carpentier Edwards PERIMOUNT valve demonstrates excellent 5-year survival, sustained haemodynamic performance, and low rates of structural valve deterioration in an Indian population.

Limitaciones

Retrospective design carries a risk of selection bias and limits the ability to establish causal relationships.
Relatively small sample size reduces statistical power and may limit the generalisability of the results.
Follow-up duration of 5 years is relatively short for the assessment of structural valve deterioration.
Predominance of smaller valve sizes (19 mm) may have influenced the observed haemodynamic outcomes.
Low number of events limits the statistical power of survival analysis.

Resumen

Background: The Carpentier Edwards PERIMOUNT valve is widely used for aortic valve replacement (AVR) due to its favourable haemodynamic profile and durability. This study evaluated durability, haemodynamic performance, survival, and clinical outcomes following AVR using this valve. Methods: This single-centre retrospective observational study included 42 patients who underwent AVR with the Carpentier Edwards PERIMOUNT valve between January 2016 to December 2016. Ethical approval was obtained prior to study initiation. Patients were followed at mid-term (6-months) and long-term (5-years). Clinical status was assessed using New York Heart Association (NYHA) functional class, and echocardiographic parameters included effective orifice area (EOA), peak pressure gradient (PPG), mean pressure gradient (MPG), peak systolic velocity (PSV), and left ventricular ejection fraction (LVEF). Survival analysis was performed using the KaplanMeier method. Results: The mean age was 67.426.51 years, and 76.19 of patients were male. Calcificdegenerative aortic valve disease was the most common aetiology (59.52). Preoperatively, patients had severe valvular obstruction with a mean EOA of 1.30.6cm² and mean pressure gradient of 54.729.5mmHg. At 5-years, sustained haemodynamic improvement was observed, with EOA of 1.90.6cm² and persistently reduced gradients (PPG 24.05.0 mmHg, MPG 12.82.5 mmHg). Functional status improved significantly, with the majority of patients in NYHA class III during follow-up. Three deaths (7.14) occurred during the follow-up period. KaplanMeier analysis demonstrated an estimated 5-year survival of 92.86. Structural valve deterioration occurred in 2.38, requiring redo AVR. Conclusions: The Carpentier Edwards PERIMOUNT valve demonstrates excellent mid-to long-term survival, sustained haemodynamic performance and significant symptomatic improvement.

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Cite This Study

Singh et al. (Sun,) conducted a observational in Aortic valve disease (n=42). Carpentier Edwards PERIMOUNT valve was evaluated on Mortality. The Carpentier Edwards PERIMOUNT valve demonstrated an estimated 5-year survival of 92.9% and a low structural valve deterioration rate of 2.38% following aortic valve replacement.

synapsesocial.com/papers/6a001ff2c8f74e3340f9b20c https://doi.org/https://doi.org/10.47799/pimr.1401.26.30

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