What question did this study set out to answer?

To explore the cellular, molecular, and epigenetic effects of 4-OH-coumarin in neuroblastoma.

May 10, 2026

Therapeutic potential of 4-OH-coumarin in neuroblastoma: cellular, molecular, and epigenetic insights.

Puntos clave

To explore the cellular, molecular, and epigenetic effects of 4-OH-coumarin in neuroblastoma.
Evaluated expressions of Parkin and piR-651 in HUVEC cells.
Analyzed cellular and molecular pathways influenced by 4-OH-coumarin.
Conducted experiments focusing on epigenetic modifications from secondary metabolites.
Parkin and piR-651 expressions significantly increased in HUVEC cells (p<0.001).
4-OH-coumarin shows potential as a therapeutic agent in cancer treatment.
Further research needed to confirm these effects in neuroblastoma models.

Resumen

<0.05), Parkin, and piR-651 expressions increased on only HUVEC cells (p<0.001). We believe that the study of various molecules that are secondary metabolites such as 4-OH-Coumarin may provide valuable data to observe the effects and mechanisms of new therapeutics that have the potential to be used for cancer treatment.

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Cite This Study

Öner et al. (Thu,) studied this question.

synapsesocial.com/papers/6a002147c8f74e3340f9c258 https://doi.org/https://doi.org/10.22099/mbrc.2025.54532.2228

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