The impact of ultraviolet radiation on skin photoaging — review of in vitro studies

BACKGROUND: Photoaging, ultra violet (UV) induced skin aging is a gradual process that depends on the time and intensity of solar radiation. AIM: The aim of this paper was to review of the literature focused on in vitro studies explaining the mechanisms of photoaging. METHODS: Electronic databases, including PubMed and MEDLINE, were searched for in vitro studies on the importance of UV radiation in the skin photoaging process of peer-reviewed scientific journals. Only articles available in English and full version publications were considered for this review. RESULTS: Three main modes of UV radiation action on skin cells which lead to photoaging, there are changes in cell metabolism, induction of oxidative stress due to the change in enzyme activity. CONCLUSION: The information gathered in this publication will help to better understand the complex and multidirectional mechanism of skin photoaging, which will contribute to the development of research on potential cosmetic products that provide effective and safe sun protection or repair damage caused by UV radiation.