High TyG-BMI was associated with significantly higher morning blood pressure surge compared to low TyG-BMI (27.50 vs. 24.50 mmHg, P=0.012) in young and middle-aged patients with primary hypertension.
Cross-Sectional (n=653)
Is a high triglyceride glucose-body mass index associated with increased morning blood pressure surge and blood pressure variability in young and middle-aged patients with primary hypertension?
Higher TyG-BMI is independently associated with increased morning blood pressure surge and blood pressure variability in young and middle-aged patients with primary hypertension, suggesting it may serve as a useful marker for cardiovascular risk stratification.
Tasa de eventos absoluta: 27.5% vs 24.5%
valor p: p=0.012
BACKGROUND AND AIMS Morning blood pressure surge (MBPS) is a significant predictor of adverse cardiovascular events in hypertension. Prior studies have also found an independent association between triglyceride glucose-body mass index (TyG-BMI) and an increased hypertension risk. Therefore, this study aimed to explore the relationship of TyG-BMI with MBPS and blood pressure variability (BPV) in young and middle-aged patients with primary hypertension (PH). METHODS AND RESULTS A total of 653 patients with PH, aged 18-65 years, were enrolled in this retrospective cross-sectional study. Patients were divided into low and high TyG-BMI groups by the median. Compared with the low TyG-BMI group, the high TyG-BMI group demonstrated significantly higher coefficient of variation (CV) of mean nocturnal systolic blood pressure (nSBP-CV), CV of mean nocturnal diastolic blood pressure (nDBP-CV), and MBPS (27.50 18.00, 38.00 mmHg vs. 24.50 17.00, 34.63 mmHg, P = 0.012). Additionally, the proportion of patients with elevated MBPS (i.e., ≥35 mmHg) in the high TyG-BMI group was slightly higher than that in the low TyG-BMI group; however, this difference was not statistically significant (P = 0.067). TyG-BMI was positively associated with MBPS and BPV (r = 0.087-0.108). Multiple linear regression analysis further showed that TyG-BMI was an independent risk factor for increased dDBP-CV, nSBP-CV, nDBP-CV, and MBPS after covariate adjustment. CONCLUSIONS TyG-BMI is an independent risk factor for increased dDBP-CV, nSBP-CV, nDBP-CV, and MBPS in young and middle-aged patients with PH.
Guo et al. (Thu,) conducted a cross-sectional in Primary hypertension (n=653). High TyG-BMI vs. Low TyG-BMI was evaluated on Morning blood pressure surge (MBPS) (p=0.012). High TyG-BMI was associated with significantly higher morning blood pressure surge compared to low TyG-BMI (27.50 vs. 24.50 mmHg, P=0.012) in young and middle-aged patients with primary hypertension.