17β-estradiol mitigated pathological microtubule remodeling, increased tricuspid plane annular systolic excursion, and enhanced right ventricular-pulmonary artery coupling in preclinical rat models.
Does 17β-estradiol improve right ventricular function and mitigate pathological microtubule remodeling in preclinical models of pulmonary hypertension?
In preclinical models of pulmonary hypertension, 17β-estradiol counteracts pathological microtubule remodeling and enhances right ventricular function, suggesting a novel cardioprotective mechanism.
Moon et al. (Thu,) conducted a other in Right ventricular dysfunction and pulmonary hypertension. 17β-estradiol vs. Vehicle (ethanol/alcohol) or control was evaluated on Right ventricular function (TAPSE, RV free wall thickening, RV-PA coupling) and microtubule density. 17β-estradiol mitigated pathological microtubule remodeling, increased tricuspid plane annular systolic excursion, and enhanced right ventricular-pulmonary artery coupling in preclinical rat models.