Versatile and Controlled Synthesis of Degradable, Water-Soluble Bottlebrush Polymers with Poly(disulfide) Backbones Derived from α-Lipoic Acid

= 650-2700 kg/mol). The easily cleavable disulfide bonds enabled backbone degradation under mild reducing conditions. Beyond hydrophilic BB with tri(ethylene glycol) methyl ether acrylate (TEGA) side chains, we synthesized BB with cationic, anionic, and zwitterionic side chains, demonstrating broad monomer compatibility. This scalable approach produces water-soluble, degradable BB polymers with tunable architectures and predictable molecular weights. By addressing the need for degradability in BB polymers, this work advances their potential for drug delivery, offering enhanced functionality, biocompatibility, and sustainability.