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strong evolutionary link between GSH and eukaryotic aerobic metabolism that is reflected in the function of GSH in protection against oxygen toxicity (2). GSH is not required in the diet of animals but is synthesized in virtually all animal cells' by the sequential actions of two enzymes: y-glutamylcysteine synthetase and GSH synthetase. A useful approach to understanding the func- tions of a cellular component such as GSH is to remove it and to determine the consequences of its deletion. GSH deficiency can be produced
A Meister (Fri,) studied this question.