All evaluated frailty diagnostic scales showed good predictive value for mortality in individuals with acute coronary syndrome, with no statistical difference between them (P=0.227).
Meta-Analysis
Does any specific frailty diagnostic scale have a better predictive value for mortality in individuals with acute coronary syndrome?
Frailty is associated with higher mortality in ACS, and various frailty scales perform similarly well in predicting this risk, allowing clinicians to choose based on practicality.
valor p: p=0.227
Background: Acute Coronary Syndrome (ACS) is a major cause of hospitalizations and deaths worldwide. Conditions such as frailty worsen these outcomes. Frailty assessment improves risk stratification, complements scores and favors personalized treatments. However, there are numerous tools available for assessing frailty, and there is still no consensus on which would be the most recommended in conditions such as ACS. The objective was to evaluate which frailty diagnostic scale has the best predictive value for mortality in individuals with ACS. Methods: This meta-analysis was conducted using Medline, Embase, and Cochrane, with a search conducted on March 5, 2024. Studies that met the PECOS criteria were included: adult and elderly individuals diagnosed with ACS, frailty assessment determined by a scale, mortality registry and intervention studies or prospective and retrospective cohorts. The risk of bias and quality of evidence were assessed by two researchers using the Joana Briggs Institute Case Series tool and the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) system, respectively. The meta-analysis was conducted using Review Manager software and subgroup analyses using R software. Results: = 0.227). The choice of scale, therefore, can be based on other factors such as practicality and availability of resources, without compromising the prognosis. Conclusion: Individuals with ACS and frailty have a higher chance of mortality, and all scales evaluated showed good predictive value, with no statistical difference. We suggest that the Clinical Frailty Scale (CFS) is suitable for hospital settings and acute conditions, such as ACS.
Cunha et al. (Sat,) conducted a meta-analysis in Acute Coronary Syndrome. Frailty diagnostic scales was evaluated on Mortality (p=0.227). All evaluated frailty diagnostic scales showed good predictive value for mortality in individuals with acute coronary syndrome, with no statistical difference between them (P=0.227).