May 15, 2021Open Access

Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study

PICO estructurado

Does greater daily glucose variability and lower time in range associate with greater aortic stiffness?

Población

853 individuals aged 40-75 years from the southern Netherlands, mean age 59.9, 49% women, 23% type 2 diabetes, who underwent at least 48 hours of continuous glucose monitoring.

Intervención

Greater daily glucose variability (assessed by standard deviation [SDCGM] and coefficient of variation [CVCGM]) and lower time in range (TIRCGM) measured via continuous glucose monitoring.

Resultado

Aortic stiffness measured by carotid-femoral pulse wave velocity (cf-PWV)surrogate

Greater daily glucose variability and lower time in range are independently associated with greater aortic stiffness, suggesting they may be potential therapeutic targets to prevent cardiovascular disease.

Resumen

AIMS: CVD is the main cause of morbidity and mortality in individuals with diabetes. It is currently unclear whether daily glucose variability contributes to CVD. Therefore, we investigated whether glucose variability is associated with arterial measures that are considered important in CVD pathogenesis. METHODS: ) with carotid-femoral pulse wave velocity (cf-PWV), carotid distensibility coefficient, carotid intima-media thickness, ankle-brachial index and circumferential wall stress via multiple linear regression. RESULTS: : -0.145 m/s -0.252, -0.038 p = 0.008) were statistically significantly associated with higher cf-PWV. Such consistent associations were not observed for the other arterial measures. CONCLUSIONS: to prevent CVD.

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