Atrial fibrillation ablation decreased maximum left atrial volume (59.0 to 53.3 cm3, P=0.001), with impaired baseline LA emptying fraction predicting functional improvement (OR 0.88, P<0.0001).
Cohort (n=115)
Does atrial fibrillation ablation improve left atrial function in patients with paroxysmal or persistent AF?
AF ablation improves left atrial function in patients with impaired baseline function, but may cause deterioration in older patients with preserved baseline function.
Tasa de eventos absoluta: 53.3% vs 59%
valor p: p=0.001
BACKGROUND: The effect of atrial fibrillation (AF) ablation on left atrial (LA) function has not been sufficiently determined. METHODS: We enrolled 115 consecutive patients with paroxysmal or persistent AF that underwent AF ablation. Multidetector computed tomography was performed in sinus rhythm before and 3 months after ablation to evaluate LA volume (LAV) and function. Estimates of maximum and minimum LAV were used to calculate LA emptying fraction (LAEF) (maximum-minimum LAV/maximum LAV × 100). RESULTS: AF ablation significantly decreased maximum LAV (59.0 ± 20.4 to 53.3 ± 16.7 cm(3) , P = 0.001), and maintained LAEF (44.5 ± 13.1% to 43.7 ± 10.9%, P = 0.49). The larger the baseline maximum LAV, the greater the decrease in LAV after ablation, and a smaller baseline LAEF was associated with a larger recovery of LAEF after ablation (regression coefficient =-0.45 and -0.56, respectively, P 10%; odds ratio OR = 0.88, P 10%; OR = 1.06, P = 0.03; and OR = 1.10, P = 0.0001). CONCLUSIONS: AF ablation appears to have a beneficial effect on LA function in patients with impaired LA function at baseline. However, it may reduce LA function in patients with an older age and preserved baseline LAEF.
Masuda et al. (Thu,) conducted a cohort in Paroxysmal or persistent atrial fibrillation (n=115). Atrial fibrillation ablation vs. Baseline (pre-ablation) was evaluated on Maximum left atrial volume (LAV) (p=0.001). Atrial fibrillation ablation decreased maximum left atrial volume (59.0 to 53.3 cm3, P=0.001), with impaired baseline LA emptying fraction predicting functional improvement (OR 0.88, P<0.0001).