Increased lipids in youth were associated with progressively worsening structural and functional cardiac damage, with systolic blood pressure and fat mass explaining circa 40% of the relationship.
Observational (n=1,595)
Do increased lipid levels associate with the risk of worsening cardiac damage in adolescents?
Increased lipid levels in youth are associated with worsening structural and functional cardiac damage over 7 years, partially mediated by blood pressure and fat mass.
BACKGROUND AND AIMS: Longitudinal evidence on the associations of changes in lipids level with changes in cardiac structure and function in youth is limited due to few repeated echocardiography measures. This study examined whether changes in lipid levels from adolescence through young adulthood associate with the risk of cardiac damage progression and potential mechanistic pathways. METHODS: and LVDF<1.5 were categorized as LV hypertrophy and LVD dysfunction, respectively. Multivariable adjusted associations were examined using generalized logit mixed-effect models and structural equation models for mediation analyses. RESULTS: . CONCLUSIONS: Increased lipids may independently associate with the risk of progressively worsening structural and functional cardiac damage in youth but increased systolic blood pressure and fat mass explained circa forty percent of the relationship.
Andrew O. Agbaje (Wed,) conducted a observational in Cardiac damage (n=1,595). Increased lipids was evaluated on Cardiac damage progression (LV hypertrophy and LVD dysfunction). Increased lipids in youth were associated with progressively worsening structural and functional cardiac damage, with systolic blood pressure and fat mass explaining circa 40% of the relationship.